Increasing workloads and resultant stresses on pharmacists have led to well-publicized staffing shortages and walkouts in the past year. The labor demands of traditional pharmacy have remained largely unchanged at a time when its role has expanded in the volume and types of therapies, across sites of care and menu of ancillary services. Through emerging artificial intelligence (AI) tools, pharmacies will enhance their operational capabilities across limited labor and better allocate pharmacist time toward potential improvements in not only productivity, but patient outcomes.  Target analysis in this environment requires an understanding of not only the emerging AI market and its applications, but federal and state regulatory and legislative trends shaping this emerging technology. Herein, we explore the opportunities and regulatory considerations of AI-integrated solutions in pharmacy.